Journal: Dental Clinics

Purpose: Discuss peripheral mechanisms of odontogenic pain Results: Function: allow peripheral terminals of nociceptors to detect & respond to noxious signals in their environment. 1.G-protein-coupled receptors (GPCRs) – neuropeptide binds to GPCR, G protein (Gαi/o, Gαq, Gαs) activation. a.Gαi/o = nerve activity inhibition. Neuropeptides: somatostatin, NPY, opioids. b.Gαq = activation of phospholipase C & protein […]

Journal: Dental Clinics

Purpose: Discuss neuropathic pain causes and mechanisms Results: Neuropathic pain described as pain initiated or caused by a primary lesion or dysfunction in the nervous system. Summarizes neuropathic pain conditions frequently seen in dental offices. –Neuropathic orofacial pain – Spontaneous pain that is unprovoked, cannot be treated with conventional analgesics or opiods –Pathophysiology – change […]