NaOCl and Chlorhexidine

Full strength NaOCl seems to be unaffected by storage up to 10 wks. However, if using diluted NaOCl, tissue dissolving ability drops significantly between weeks 1 and 2

Full strength NaOCl gives the highest antimicrobial activity potential, and mixing with organic matter may alter antimicrobial activity against S. faecalis.

In non-confined areas, NaOCl has a strong, non-specific, surface-acting solvent action on vital pulp tissue. In vital teeth, it may present a challenge to conventional RCT. It is very important to clean and shape all canals. NaOCL has limited action in confined areas.

5.25 % NaOCl is the best tissue dissolving irrigant and diluting it decreases its tissue-dissolving capability

NaOCl is more effective vs. saline in dissolving pulp tissue and cleaning wider area of canals.