Analysis of clinical toxicity of endodontic irrigants

By Kollmann W

Date: 01/1978
Journal: JOE


  • Purpose: To compare the clinical toxicity of 5.25% NaOCl, 5.25% NaOCl+3% H2O2, saline.
  • N=253 cases, inclusion criteria: no pre-operative pain.
  • Materials/Methods:

  • Procedure done by 2 endodontist, using common technique, rubber dam isolation.
  • Irrigation groups :G1, saline, G2 5.25% NaOCl, G3 5.25% NaOCl/ 3% H2O2. 1 ml was used after each instrument.
  • Tooth sealed with cotton pellet and cavit. Tooth,# roots, prior emergency TX, PA lesion, status of the pulp (vital if bleeding observed) were recorded.
  • Patients returned after 2-14 days. Scored their pain : none, slight (no need for analgesic/other palliative TX).moderate and sever (need medication/ palliative TX).
  • Most highlighted Results:

  • Overall: no pain (66%), slight (28%),severe to moderate (7%).
  • No difference in incidence and degree of pain in vital , non vital, teeth with or without PA lesion and single rooted teeth.
  • Incidence of pain in multirooted teeth was significantly less in 5.25% NaOCl/ 3% H2O2 group compared to saline group. No difference between G2,G3.
  • No difference in the degree of pain among groups.
  • When comparing all groups, incidence of pain in vital vs. non-vital, teeth with PA vs. no PA, multirooted vs single was not statistically significant.

Clinical significance:

In term of post-operative pain NaOCl was not different from saline, which suggest that clinical toxicity observed in NaOCl is not as that found in vitro