Efficacy of Epinephrine Concentration in Local Anesthesia During Periodontal Surgery

By Buckley JA, Ciancio SG, McMullen JA

Date: 07/1984
Journal: Journal Periodontal


Purpose: to compare the two concentrations of 2% lidocaine combined with either 1:50,000 or 1:100,000 epinephrine  relative to their effect on blood loss in comparable surgical procedures performed on the same patient.

N = 10 patients need surgical correction of periodontal defects.


•Before anesthesia & surgery; bleeding time, baseline blood pressure, pocket depth and the gingival index were measured.

•No aspirin intake at least 36 hours before surgery. •Same operator performing all surgeries.

•If bilateral surgery planned, each side received a different epinephrine local anesthetic concentration.

•Blood loss was measured using the cyanmethemoglobin comparison technique.

•Blood loss was calculated by comparing the concentration of the Hb in the patient’s whole blood with the concentration of Hb in the collected blood.

Most highlighted Results: 

1.Generally, the longer the procedure the ⬆️ quantity of epinephrine needed ⬆️ blood loss.

2.Patients who received lidocaine HCl 2% with 1:50,000 epinephrine had considerably less blood loss.

Clinical significance:

•Procedures using lidocaine 2% with 1:100,000 epinephrine generally had more than twice as much blood loss as those using lidocaine 2% with 1:50,000 epinephrine.