Hemostatic Efficacy and Cardiovascular Effects of Agents Used During Endodontic Surgery

By Vickers F J , Baumgartner JC , Marshall G

Date: 12/2002
Journal: JOE


Purpose: To evaluate ferric sulfate and epinephrine-impregnated cotton pellets and  their ability to achieve hemostasis during endodontic surgical procedures and for cardiovascular changes


•33 patients participated in this study

•The patients were randomly assigned to one of two groups.

In group I, hemostasis was achieved by using 20% ferric sulfate.

In group 2, hemostasis was achieved by using racemic-epinephrine cotton pellets.

•Blood pressure was recorded preoperatively , immediately after surgery and before patients dismissal

A Most highlighted Results: 

  1.There were no significant changes in blood pressure or pulse at any time period for experimental groups 1 and 2

2.. In group 1 (ferric sulfate), adequate hemostasis was achieved in 15 out of 16 cases, with one case having inadequate hemostasis.

3.In group 2 (epinephrine pellets), adequate hemostasis was achieved in all 17 cases.

4.Racellet #3 pellets contain an average of 0.55 mg (0.42 to 0.68 mg/pellet) of racemic-epinephrine hydrochloride per pellet,

Clinical significance: 

.  Using the racemic epinephrine pellets showed good  hemostasis in endodontic surgery .