The role of preoperative prophylactic antibiotic administration in periapical endodontic surgery: a randomized, prospective double-blind placebo-controlled study

By Lindeboom JAH, Frenken JWH, Valkenburg P, van den Akker HP.

Date: 05/2006
Journal: JOE


Purpose: To determine the value of clindamycin prophylaxis in the prevention of postoperative wound infections in patients undergoing endodontic surgery

N= 256 patients (age range 18–82 years )

Materials/Methods: §After randomization the patient blindly received either a single dose of 600 mg clindamycin or placebo 1 h before incision §No preoperative surgical rinsing protocols with chlorhexidine 0.12% were used §The surgical flap procedure was similar for all selected teeth §Postoperatively Ibuprofen 600 mg 3/day for 5 days, rinse with 0.2% chlorhexidine 2/day for 1 week §Patients were assessed 1,2 and 4 weeks after surgery, the wound was inspected for signs of infection

Most highlighted Results: 1.6 infections were identified in 256 patients, giving an overall infection rate of 2.3% 2.2 infections were identified in the clindamycin group and 4 in the placebo group, with no significant difference in the prevention of postoperative infection in endodontic surgical procedures

Clinical significance:

Prophylactic antibiotics has no significant effect on postoperative infections