Hemostatic Efficacy and Cardiovascular Effects of Agents Used During Endodontic Surgery

By Vickers F.J., Baumgartner J.C., Marshall G.

Date: 01/2002
Journal: JOE


The hemostatic efficacy, as well as the cardiovascular effects of racemic-epinephrine pellets (Racellet pellets) vs. 20% ferric sulfate (Viscostat).


  • N=39 for periapical surgery, Inclusion: ASA class I & II. Group 1=ferric sulfate Group 2= racellet pellets.
  • Blood pressure and pulse rate were recorded pre- and postoperatively and at at 1, 5, and 10 min after placement.
  • The adequacy of hemostasis was rated by the surgical operator.


  1. Surgical hemostasis achieved in 15 out of the 16 treated with Ferric Sulfate and all 17 cases treated with racemic-epinephrine pellets.
  2. No significant change in cardiovascular effects when using either of these hemostatic agents.

Clinical Significance:

Racemic-epinephrine (Epinephrine concentration # 2 = 0.55 mg/pellet) pellets can be used for hemostasis with no cardiovascular effect.