Journal: Arch Oral Biol
- Cochrane conceived the basic concept of systematic reviews and is now considered one of the pioneers and founders of evidence-based medicine.
- The systematic review incipiently recommended by Cochrane in 1972 has undergone many changes and improvements in the last four decades.
- Cochrane Collaboration (www.cochrane.org) has a role in orienting, preparing and maintaining systematic reviews.
- The first point that should guide a systematic review is always the key question (PICO Strategy).
- Then, at the heart of a systematic review is its search strategy, which represents 80% of the quality level of a study.
- Large databases such as PubMed, EMBASE and Science Direct can be used in the search for scientific evidence on a particular subject.
- After data search and later inclusion of articles based on the eligibility criteria, articles should be evaluated for their quality.
- Another factor that often is neglected by authors of systematic reviews is the influence of data heterogeneity, both in statistical analysis and in the discussion of the work.
- To answer the question .. many systematic reviews should not be ranked at the top of the scientific evidence pyramid.
- The reason is that many basic precautions are often not taken, generating systematic reviews with a less than satisfactory level of scientific evidence about the subject being studied.