Irrigants for non-surgical root canal treatment in mature permanent teeth (Review)

By Fedorowicz Z, Nasser M, Sequeira-Byron P, de Souza RF, Carter B, Heft M.

Date: 05/2013
Journal: Cochrane Database Syst Rev


Purpose: To assess the effects of irrigants used in the non-surgical root canal treatment of mature permanent teeth.


 Search was conducted using Chochrane, MEDLINE, EMBASE, and LILACS up to 5th of July 2012

Inclusion & Exclusion:

were stated

– n: 11 trials involving 851 participants with 879 teeth


             –     4 studies (Bashetty 2010; Ercan2004;Ringel 1982;Vianna 2006) concluded that there were No significant difference between NaOCL and CHX in reducing the bacterial growth with different conc. and form (gel or solution)

-1 study  (Soares 2006) concluded that there were a difference between 1% NaOCL concertation and 5% NaOCL in the number of positive cultures (but not significant)

-1 study (Harrison 1978) concluded that there were no evidence supporting the effect of different irrigation solutions (saline, 5.25% NaOCL, 5.25% NaOCL with 3% Hydrogen peroxide) to interappointment pain.

-1 study (Tachieri 2009) concluded that there were no notable difference between 5% NaOCL and 5% NaOCL with proteolytic enzyme in post-operative pain and cases with new or worsening S&S.

-Zamany 2003 reported no sig difference in bacterial growth following final irrigation with either 2% CHX or saline after initial irrigation with 1% NaOCL.

– Malkhassian 2009 reported reduced bacteria when 1.3% NaOCL used with MTAD than when saline used alone

-Bebeck 2009 reported difference of bacterial growth between 2% CHX and saline

-Torbinejad 2005 reported average pain at day 7 in both irrigation regime (Sodium hypochlorite 5.25% with EDTA (17%) versus sodium hypochlorite 1.3% with MTAD)


There was insufficient clear evidence to support the outright superiority of any specific individual irrigant or irrigating regime.