- This study tested the hypothesis that the systemic administration of statins results in increased dental pulp calcification.
- N= 90 (45 test, 45 control)
- Exclusion criteria: Previous pulp cap treatment, history of clenching/grinding
- Inclusion criteria: (1) 60 years old+, (2) taking a statin medication, and (3) posterior bitewing radiographs with excellent diagnostic quality.
- Positive/negative control: Age-matched control group of patients not taking any medications was
- Control & Design: 34 first molars and 56 second molars were selected at University of North Carolina, BW radiographs were taken w/#2 phosphor plates w/Rinn XCP. Exposures of 70 kVP, 7 mA, for 0.2-0.3 s. Measurements taken using single examiner. 4 different linear measurements taken – 2 horizontal, 2 vertical. These were analyzed as ratios, and compared between control and test groups.
- Criteria of evaluation: Reduced pulp height/width evaluated using Image J software, and analyzed using t tests and multiple linear regression models.
- Significant reduction in pulp chamber height noted in statin group compared to control group. 3/45 of molar teeth in test group exhibited near-completed obliteration of pulp chamber (not seen in control group). Not statistically significant for reduction of width on teeth.
Possible odontoblasticactivation by statins may lead to reduced pulp chamber height in patients. Other factors may be involved in the process: other meds, atherosclerosis, etc, thus reduction may not be strictly due to statins. Larger patient sample needed to study this effect.